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Fibroids that distort the uterine cavity have an impact on the ability of an embryo to implant and should be removed surgically. Eating disorders: If an eating disorder leads to serious weight loss, fertility problems may arise. Aromatase inhibitors Aromatase inhibitors (letrozole, anastrozole) inhibit the action of the enzyme aromatase, which converts androgens into estrogens by a process called aromatization.

I cannot stress enough how amazing this staff is, they make you feel like family! Luciano AA, Peluso J, Koch EI, Maier D, Kuslis S, Davison E. Apparent Fertility of Human Spermatozoa from the Caput Epididymidis. (PDF, 4 MB) Journal of Andrology, 1989.

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For men, a visual inspection of sexual characteristics can identify such endocrinopathies as hypogonadism (a condition resulting in atrophy or deficient development of secondary sexual characteristics) or Klinefelter’s syndrome (a genetic anomaly often associated with infertility). Passive smoking has also been linked to lower fertility. The man is advised not to ejaculate for 2 to 3 days before giving the semen sample for evaluation. Couples may decide to go ahead regardless if the desire to become pregnant is very strong. Enzymatic Digestion of Testicular Tissue May Rescue the Intracytoplasmic Sperm Injection Cycle in Some Patients with Non-obstructive Azoospermia. (PDF, 66 KB) Human Reproduction, 1998. The use of Epididymal and Testicular Sperm for ICSI. (PDF, 1 MB) From IX World Congress on In Vitro Fertilization and Alternated Assisted Reproduction, 1995.

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37,38 The addition of 1,500 to 1,700 mg of metformin (Glucophage) daily may increase ovulation and pregnancy rates, but it does not significantly improve live birth rates over clomiphene alone. Possible causes include the egg not being released at the right time, the egg’s inability to reach the fallopian tube, or the sperm’s inability to reach the egg. Fertility awareness methods are used to discern when these changes occur by tracking changes in cervical mucus or basal body temperature. Temporal relationship and reliability of the clinical, hormonal, and ultrasonographic indices of ovulation in infertile women. 6 Women with risk factors for tubal obstruction, such as endometriosis, previous pelvic infections, or ectopic pregnancy, should instead be offered hysteroscopy or laparoscopy with dye to assess for other pelvic pathology. Varicocele: Surgically removing a varicose vein in the scrotum may help.

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XX male (sex reversal syndrome) An XX karyotype is due to a crossover of the sex-determining region (SRY) of the Y chromosome (with the testis determining factor) to either the X chromosome or an autosome. Religious leaders' opinions on fertility treatments; for example, the Roman Catholic Church views infertility as a calling to adopt or to use natural treatments (medication, surgery, or cycle charting) and members must reject assisted reproductive technologies. A doctor injects sperm directly into the egg in a dish and then places it into your uterus. Factors contributing to the formation of antisperm antibodies in women are disturbance of normal immunoregulatory mechanisms, infection, violation of the integrity of the mucous membranes, rape and unprotected oral or anal sex. 8,26,27 As opposed to laparoscopy or hysteroscopy, hysterosalpingography is a minimally invasive procedure with potentially therapeutic effects and should be considered before more invasive methods of assessing tubal patency. IUI with the partner’s sperm can be used as a potentially effective treatment for infertility in women under age of 45 except for cases with tubal blockage, very poor egg quality, ovarian failure and severe male factor infertility (very low sperm count or very poor sperm shape or mobility). Some suggest that the number of times a couple has intercourse should be reduced to increase sperm supply, but this is unlikely to make a difference. If a semen analysis is found to be abnormal, generally it is first repeated to confirm the abnormality.