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The most common disorders impacting ovulation include polycystic ovary syndrome (PCOS), hypogonadotropic hypogonadism (from signaling problems in the brain), and ovarian insufficiency (from problems of the ovary). 50% are female causes with 25% being due to anovulation and 25% tubal problems/other.[74] In Sweden, approximately 10% of couples wanting children are infertile.[75] In approximately one third of these cases the man is the factor, in one third the woman is the factor, and in the remaining third the infertility is a product of factors on both parts. Mannitol Induced Central Nervous System Toxicity in Renal Failure. (PDF, 4 MB) Investigative Urology, 1972. Testicle pain or swelling There are several different conditions that could lead to pain or swelling in the testicles, many of which could contribute to infertility.

A Physical Map of the Human Y Chromosome. (PDF, 160 KB) Nature, 2001. Obese women have a higher rate of recurrent, early miscarriage compared to non-obese women. European Association of Urology guidelines on male infertility: the 2012 update.

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Three modalities are used to treat myomas: medical treatment, surgical treatment, and embolization. Fresh Ovarian Tissue and Whole Ovary Transplantation. (PDF, 373 KB) Seminars in Reproductive Medicine, 2009. Seventy-five percent of patients have testicular atrophy and primary testicular failure due to degeneration of the seminiferous tubules.

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Illegal drugs: Consumption of marijuana and cocaine can lower the sperm count. The most commonly prescribed pill to stimulate ovulation (generally of one mature egg) is clomiphene citrate. Endometriosis  Endometriosis is a condition where the inner lining of the uterus, known as the endometrium, attaches and grows in other areas. Normal Fertilization of Human Oocytes after Testicular Sperm Extraction and Intracytoplasmic Sperm Injection.(PDF, 2 MB) Fertility and Sterility, 1994.

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47 Motivational interviewing techniques for modifiable risk factors, such as obesity, tobacco, illicit drugs, and alcohol, can decrease the targeted risk factor. Factors effecting normal expectancy of conception. Evaluation should be pursued by 6 months of attempted pregnancy in women with a known history of these abnormalities or a history of bleeding between menstrual cycles. Because the sperm have a short life span outside the human body, the semen specimen must be evaluated within a short time frame. Regrettably, this often leads to untruly high expectations of assisted reproduction techniques (ART) [40]. A causal therapeutic approach does not exist and an important component is the prevention of hyperstimulation syndrome. Clinical examination Full clinical examination of both partners usually stands for the underlying physical problem [17-22,24-26], (Appendix 2).