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The etiology is unknown but is probably multifactorial. Partners may become more anxious to conceive, increasing sexual dysfunction.[17] Marital discord often develops, especially when they are under pressure to make medical decisions.

Ovulation induction is somewhat different from controlled ovarian hyperstimulation, which involves the use of some of the same medications to stimulate the development of multiple mature follicles and eggs in order to increase pregnancy rates with various infertility treatments. Trauma, previous attempts at sperm aspiration, and inguinal surgery may also result in ductal blockage.

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Some causes are more common in some countries than others, such as pelvic inflammatory diseases (PID) and sexually transmitted infections (STI) in Africa [10]. Antisperm antibodies may form when the blood-testis barrier is breached because of infection, vasectomy, testicular torsion, cryptorchidism, or testicular trauma. A cumulative pregnancy rate of 80% is achieved during the first 6 cycles of therapeutic insemination. Bushnik T, Cook JL, Yuzpe AA, Tough S, Collins J. The Treatment of Azoospermia with Surgery and ICSI. (PDF, 4 MB) Chapter 10 from Male Fertility & Infertility, 1998.

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Trauma, previous attempts at sperm aspiration, and inguinal surgery may also result in ductal blockage. High environmental temperature and excessive conditioning resulting in increased body temperature can induce either temporary or permanent azoospermia. It is increasingly recognized that egg quality is of critical importance and women of advanced maternal age have eggs of reduced capacity for normal and successful fertilization. Sperm Retrieval for Azoospermia and Intracytoplasmic Sperm Injection Success Rates – A Personal Overview.(PDF, 1 MB) Human Fertility, 2010.

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If conservative medical treatments fail to achieve a full term pregnancy, the physician or WHNP may suggest the patient undergo in vitro fertilization (IVF). The chance of a multiple birth is lower with an oral fertility drug. The pituitary gland controls most other hormonal glands in the human body. Women with anovulation may be treated in the primary care setting with clomiphene to induce ovulation. It is very important that these injuries be recognized as early as possible.[26] Some patients have sustained electrical burns unseen by surgeons who are working with electrodes that leak current into surrounding tissue. A spermiogram control study is performed after 3 cycles of therapy.