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44 Therefore, a simple recommendation is for vaginal intercourse every two to three days to optimize the chance of pregnancy. If natural selection is the primary error correction mechanism that prevents random mutations on the Y chromosome, then fertility treatments for men with abnormal sperm (in particular ICSI) only defer the underlying problem to the next male generation. However, in our modern era, women are delaying child birth until their thirties and forties, which has lead to the discovery of the adverse effect of advanced maternal age on egg function. Additionally, the sperm may be unable to cross the cervical mucus or may have ultrastructural abnormalities. In some cases this can also cause considerable pain when breathing. Microscopic Vasectomy Reversal 30 Years Later: A Summary of 4010 Cases by the Same Surgeon. (PDF, 295 KB)Journal of Andrology, 2004.

Laboratory studies have suggested that long-term acetaminophen use during pregnancy may affect fertility in males by lowering testosterone production. On Regenerating the Ovary and Generating Controversy. (PDF, 37 KB) Cell, 2005. Hypothyroidism: Low thyroid hormone levels--can cause poor semen quality, poor testicular function and may disturb libido.  May be caused by a diet high in iodine.  Reducing iodine intake or beginning thyroid hormone replacement therapy can elevate sperm count.  This condition is found in only 1 percent of infertile men. Ovarian Transplantation between Monozygotic Twins Discordant for Premature Ovarian Failure. (PDF, 315 KB) The New England Journal of Medicine, 2005. Your doctor may suggest that you take gonadotropin if you have unexplained infertility or when other kinds of treatment haven't helped you get pregnant. This can make it difficult for the embryo to implant.

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Each day of abstinence is typically associated with an increase in semen volume of 0. VITRIKAS, MD, David Grant Medical Center Family Medicine Residency, Travis Air Force Base, California Am Fam Physician. 2015 Mar 1;91(5):308-314.   Patient information: See related handout on infertility, written by the authors of this article.   Related letter: Natural Procreative Technology for Treating Infertility This clinical content conforms to AAFP criteria for continuing medical education (CME).

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Ovulation-inducing drugs and ovarian cancer risk: results from an extended follow-up of a large United States infertility cohort. At least one open tube is required for IUI, and any sperm abnormality cannot be severe, otherwise the sperm will not be able to swim to and fertilize the egg. Fallopian tubes that are patent and will function to permit the sperm and ovum to meet and allow migration of the conceptus to the uterus.

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In my case, the inability to conceive was the result of a condition called stage 4 endometriosis. ICSI with Epididymal and Testicular Sperm in Azoospermic Men. (PDF, 2 MB) From Treatment of Infertility: The New Frontiers, 1998. Many health conditions can make it hard to get pregnant. Cervical factors are also thought to play a minor role, although they are rarely the sole cause. Sperm can survive as long as 5 days in the female genital tract. This technique involves an injection of a single healthy sperm directly injected into mature egg. 50% are female causes with 25% being due to anovulation and 25% tubal problems/other.[74] In Sweden, approximately 10% of couples wanting children are infertile.[75] In approximately one third of these cases the man is the factor, in one third the woman is the factor, and in the remaining third the infertility is a product of factors on both parts.