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Acquired causes include tumor, infarction, radiation, infection, or granulomatous disease. Sterilisation involves blocking the fallopian tubes to make it impossible for an egg to travel to the womb. Reproductive Biology. (PDF, 147 KB) The Scientist, 1996.

Effect of metformin on ovulation and reproductive outcomes in women with polycystic ovary syndrome: a meta-analysis of randomized controlled trials. A variety of disorders ranging from hormonal disturbances to physical problems, to psychological problems can cause male infertility.  Although many treatment options are now available, in many cases treatment will not work.  In many instances, male infertility is caused by testicular damage resulting in an inability of the testicle to produce sperm.  Once damaged, the testicle will not usually regain its sperm-making capabilities; this aspect of male infertility is analogous to menopause (though not natural like menopause) for women and cannot usually be treated.  Despite medicine�s limited ability to treat male infertility, many successful treatment options are available for its many causes.  Besides testicular damage, the main causes of male infertility are low sperm production and poor sperm quality.   The Causes of Male Infertility Male infertility has many causes--from hormonal imbalances, to physical problems, to psychological and/or behavioral problems.  Moreover, fertility reflects a man�s �overall� health.  Men who live a healthy lifestyle are more likely to produce healthy sperm.  The following list highlights some lifestyle choices that negatively impact male fertility--it is not all-inclusive: · Smoking--significantly decreases both sperm count and sperm cell motility. · Prolonged use of marijuana and other recreational drugs. · Chronic alcohol abuse. · Anabolic steroid use--causes testicular shrinkage and infertility. · Overly intense exercise--produces high levels of adrenal steroid hormones which cause a    testosterone deficiency resulting in infertility. · Inadequate vitamin C and Zinc in the diet. · Tight underwear--increases scrotal temperature which results in decreased sperm production. · Exposure to environmental hazards and toxins such as pesticides, lead, paint, radiation, radioactive   substances, mercury,  benzene, boron, and heavy metals · Malnutrition and anemia. · Excessive stress! Microsurgery for Vasectomy Reversal and Vasoepididymostomy. (PDF, 13 MB) Urology, 1984. Clark AM, Thornley B, Tomlinson L, Galletley C, Norman RJ.

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These are agents that support the follicular maturation and the secretion of gonadotropins. This results in negative feedback stimulation of the hypothalamic-pituitary axis, causing an increase release of gonadotropins and testosterone.

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Its use has been extended to assisted reproduction technologies. Summary Infertility is a significant medical and social problem affecting couple worldwide. It is a sensitive issue that should be handled with great care with continuous professional counselling. Most young couples will conceive naturally within 2 years. Evaluation of both partners for causes is essential. Treatment depends on the cause, and varies from medical treatment to surgery to ART. They can also carry out some basic tests on both partners to see if there is an identifiable reason for not having achieved a pregnancy.

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Therefore, we recommend an evaluation if menstrual cycles are infrequent or irregular in a couple attempting pregnancy. 8 Evaluation of Men Jump to section + Causes of male infertility include infection, injury, toxin exposures, anatomic variances, chromosomal abnormalities, systemic diseases, and sperm antibodies. To analyze tubal causes of sterility, different methods can be considered. The prevalence varies widely, being less in developed countries and more in developing countries where limited resources for investigation and treatment are available [2]. A specific portion of the androgen receptor gene, exon 1, has been studied in infertile males and a meta-analysis that involved males with idiopathic infertility and fertile controls found that infertility was directly correlated with the length of CAG repeats in this exon.[23] Y chromosome microdeletion syndrome The long arm of the Y chromosome (Yq) is considered critical for fertility, especially Yq11. The views expressed in this material are those of the authors, and do not reflect the official policy or position of the U. Efficacy of laparoscopy is inferior to open surgery in certain conditions such as pyloromyotomy for Infantile hypertrophic pyloric stenosis. To verify azoospermia, the semen should be centrifuged and evaluated under a light microscope for the presence of sperm. However, medical treatment can be used to reduce the myoma size prior to removal. The hypothalamus, the primary integration center, responds to various signals from the central nervous system (CNS), pituitary gland, and testicles to secrete gonadotropin-releasing hormone (GnRH) in a pulsatile pattern approximately every 70-90 minutes.