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Genetics of Male Infertility: Evolution of the X and Y Chromosome and Transmission of Male Infertility to Future Generations. (PDF, 10 MB) Chapter 5 from Essential IVF, 2004. Additionally, because insulin-like growth factor (IGF) has been shown to have an effect on semen quality, its role in varicocele pathology has been studied.[25] One study showed that IGF levels significantly increased after a varicocelectomy to levels that were no different than fertile controls, suggesting that varicocele-related infertility may involve IGF.[26] Varicoceles lead to an increased incidence of sperm immaturity, apoptosis, and necrosis with severe disturbances in meiotic segregation compared to fertile men without varicoceles, and these parameters generally improve after repair. In-vitro fertilization and donor insemination are major procedures involved. Once confirmed, the male partner is referred to a reproductive urologist, especially if the abnormality is severe. It is usually not the natural state of a healthy adult, except notably among certain eusocial species (mostly haplodiploid insects). Microsurgical Solutions to Male Infertility. (PDF, 2 MB) Contemporary OB/GYN, 2005.

Sherman Silber: Be Fruitful and Multiply. (PDF, 6 MB) Lifestyles Magazine, 1999. World Health Organization reference values for human semen characteristics.

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PDF Articles by Decade: 1970s | 1980s | 1990s | 2000s | 2010s ARTICLES FROM THE 1970s Active Lupus Glomerulitis and Hematoxylin Bodies with Normal Urinalysis. (PDF, 5 MB) The Journal of Urology, 1971. Definition “A woman of reproductive age who has not conceived after 1 year of unprotected vaginal sexual intercourse, in the absence of any known cause of infertility” NICE guideline, CG156 Primary infertility; couple have failed to conceive before. Secondary infertility; woman has previously been pregnant regardless of the outcome of the pregnancy and now unable to conceive. Passive smoking has also been linked to lower fertility. Celiac disease A digestive disorder caused by sensitivity to gluten, celiac disease can cause male infertility.

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Patients with this type of uterus can have a normal term pregnancy. MESA or TESA? (PDF, 115 KB) Human Reproduction, 1996. Down syndrome These patients have mild testicular dysfunction with varying degrees of reduction in germ cell number. The corollary to this is that, by definition, failure to conceive in women under 35 isn't regarded with the same urgency as it is in those over 35.

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For women, being underweight and having extremely low amounts of body fat are associated with ovarian dysfunction and infertility and they have a higher risk for preterm birth. Success rates for induction of ovulation vary considerably and depend on the age of the woman, the type of medication used, the presence of other infertility factors present in the couple and other reasons. Are Sequence Family Variants Useful for Identifying Deletions in the Human Y Chromosome? (PDF, 377 KB) The American Journal of Human Genetics, 2004. Medical management: - Men with hypogonadotrophic hypogonadism should be offered gonadotrophin drugs. - Men with idiopathic semen abnormalities should not be offered anti-oestrogens, gonadotrophins, androgens, bromocriptine or kinin-enhancing drugs. Problems with sexual intercourse These can include trouble keeping or maintaining an erection sufficient for sex (erectile dysfunction), premature ejaculation, painful intercourse, anatomical abnormalities such as having a urethral opening beneath the penis (hypospadias), or psychological or relationship problems that interfere with sex. New Treatment for Infertility Due to Congenital Absence of Vas Deferens. (PDF, 1 MB) The Lancet, 1987. 41 Treatment of Unexplained Infertility Jump to section + Couples who have no identified cause of infertility should be counseled on timing of intercourse for the most fertile period (i.e., the six days preceding ovulation). A Family of Human Y Chromosomes has Dispersed Throughout Northern Eurasia Despite a 1. Patients present with oligospermia but have LH levels within the reference range. 8 Evaluation of Men Jump to section + Causes of male infertility include infection, injury, toxin exposures, anatomic variances, chromosomal abnormalities, systemic diseases, and sperm antibodies. Linthicum, Md.: American Urological Association, Inc.; 2010.