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In some women, and especially with age, the membrane becomes harder. Other factors that can affect a woman's chances of conceiving include being overweight or underweight,[56] or her age as female fertility declines after the age of 30.[57] Sometimes it can be a combination of factors, and sometimes a clear cause is never established. 6-Mb Deletion of the Human Y Chromosome Persists Through Balance Between Recurrent Mutation and Haploid Selection. (PDF, 295 KB) Nature Genetics, 2003. Ultrasound: This may reveal issues such as ejaculatory duct obstruction or retrograde ejaculation. Povey AC, Clyma JA, McNamee R, et al.; Participating Centres of Chaps-UK.

Abnormality in any of those regions may indicate abnormal sperm function and compromise the ability of sperm to fertilize the egg. Sulfasalazine: This anti-inflammatory drug can significantly lower a man's sperm count. A needle biopsy of the testicle can show whether a man is making healthy sperm. Diet: A lack of folic acid, iron, zinc, and vitamin B-12 can affect fertility. Clark AM, Thornley B, Tomlinson L, Galletley C, Norman RJ.

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It can also help if a man has severe erectile dysfunction. In the majority of cases, there are no obvious symptoms that you may be infertile. Ectopic pregnancy This is when a fertilized egg implants outside the womb, usually in a fallopian tube. Aetiology of Congenital Absence of Vas Deferens: Genetic Study of Three Generations. (PDF, 4 MB) Human Reproduction, 1993.

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The volume provides clear guidelines and a logical sequence of steps which will quickly lead the clinician or physician to an accurate diagnosis of the underlying cause of infertility. Low sperm mobility (motility): The sperm cannot "swim" as well as they should to reach the egg. Fertility: assessment and treatment for people with fertility problems.

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Congenital blockage of the ductal system An increased rate of duct obstruction is observed in children of mothers who were exposed to DES during pregnancy. In these methods, fertilization occurs inside the body. Blood test: This can assess hormone levels and whether a woman is ovulating. When the eggs are mature, your doctor collects them with a device called a vaginal ultrasound probe. Its use is controversial in patients with a history of breast cancer. Prior surgeries Certain surgeries may prevent you from having sperm in your ejaculate, including vasectomy, inguinal hernia repairs, scrotal or testicular surgeries, prostate surgeries, and large abdominal surgeries performed for testicular and rectal cancers, among others. Uterine surgery: - Women with amenorrhoea who are found to have intrauterine adhesions should be offered hysteroscopic adhesiolysis because this is likely to restore menstruation and improve the chance of pregnancy. Common causes of infertility of females include: ovulation problems (e.g. polycystic ovarian syndrome, PCOS, the leading reason why women present to fertility clinics due to anovulatory infertility.[58]) tubal blockage pelvic inflammatory disease caused by infections like tuberculosis age-related factors uterine problems previous tubal ligation endometriosis advanced maternal age immune infertility Males[edit] The main cause of male infertility is low semen quality. The gonadotropins in these formulations are FSH, and in some cases, a combination of FSH and LH (luteinizing hormone).