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Quantitative Evaluation of Spermatogenesis by Testicular Histology in Men with Congenital Absence of the Vas Deferens Undergoing Epididymal Sperm Aspiration. (PDF, 3 MB) Human Reproduction, 1990. Tourism[edit] Fertility tourism is the practice of traveling to another country for fertility treatments.[68] It may be regarded as a form of medical tourism. Overheated testicles: Causes include an undescended testicle, a varicocele, or varicose vein in the scrotum, the use of saunas or hot tubs, wearing tight clothes, and working in hot environments. On the day of ovulation, a mucus sample is taken after intercourse. 6,8 It is important for primary care physicians to be familiar with the workup and prognosis for infertile couples.

They may benefit from referral to a physician comfortable with prescribing pulsatile administration of gonadotropin-releasing hormone or gonadotropins with luteinizing hormone activity to induce ovulation. Transplantation of Rat Kidneys with Acute Tubular Necrosis into Salt-loaded and Normal Recipients. (PDF, 2 MB)Surgery, 1975.

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Affected individuals displayed more severe forms of infertility such as azoospermia and severe oligozoospermia.[27] Other causes[edit] Factors that can cause male as well as female infertility are: DNA damage DNA damage reduces fertility in female ovocytes, as caused by smoking,[28] other xenobiotic DNA damaging agents (such as radiation or chemotherapy)[29] or accumulation of the oxidative DNA damage 8-hydroxy-deoxyguanosine[30] DNA damage reduces fertility in male sperm, as caused by oxidative DNA damage,[31] smoking,[28] other xenobiotic DNA damaging agents (such as drugs or chemotherapy)[32] or other DNA damaging agents including reactive oxygen species, fever or high testicular temperature.[33] The damaged DNA related to infertility manifests itself by the increased susceptibility to denaturation inducible by heat or acid [34] or by the presence of double-strand breaks that can be detected by the TUNEL assay.[35] General factors Diabetes mellitus,[36][37] thyroid disorders,[38] undiagnosed and untreated coeliac disease,[39][40][41][42] adrenal disease[43] Hypothalamic-pituitary factors Hyperprolactinemia Hypopituitarism The presence of anti-thyroid antibodies is associated with an increased risk of unexplained subfertility with an odds ratio of 1. Understanding what defines normal fertility is crucial to helping a person, or couple, know when it is time to seek help. Primary infertility is when a couple has not conceived after trying for at least 12 months without using birth control Secondary infertility is when they have previously conceived but are no longer able to. To analyze tubal causes of sterility, different methods can be considered. Chemotherapy: Some chemotherapy drugs can result in ovarian failure. Because cortisol is not secreted, a lack of feedback inhibition on the pituitary gland occurs, leading to adrenocorticotropic hormone (ACTH) hypersecretion.

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Kidney Transplantation in Inbred Rats. (PDF, 6 MB) The American Journal of Surgery, 1973. Today, assisted reproductive techniques (ARTs) offer powerful new options.

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Syndromes such as Klinefelter’s syndrome, cystic fibrosis, Kallmann’s syndrome, and Kartagener’s syndrome. Coping mentally It is impossible to know how long treatment will go on for and how successful it will be. Sexually transmitted infections (STIs): Chlamydia can damage the fallopian tubes in a woman and cause inflammation in a man's scrotum. Reduced fecundability in women with prenatal exposure to cigarette smoking. Ideally, the cause of the infertility is reversible and then conception can result from natural sex. The success rate of IVF for live birth is 40% among women under 35 years of age. Factors Affecting Fertility: Timing of Intercourse Intercourse prior to ovulation is key to maximizing the chance of pregnancy. This prevents the sperm from fertilizing the egg. 42 Urinary luteinizing hormone kits indicate the midcycle luteinizing hormone surge that precedes ovulation by one to two days. Endometriosis Endometriosis is when the tissue of the uterine lining grows outside of the uterus. Further investigations 18. Laparoscopy: - Invasive procedure. - to check for pelvic disease; such as endometriosis and to check tubal patency. - therapeutic as in laparoscpic myomectomy and ovarian drilling. Hysteroscopy: - to evaluate uterine cavity. - In case of repeated failed IVF cycles. - therapeutic as in intrauterine septum. A mouse study has suggested that ingredients in some household detergents may reduce fertility. Absence of mastodynia (breast pain or tenderness) occurs in about 20% of women with ovulatory problems.