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Intracytoplasmic sperm injection is a process by which semen is washed and prepared for direct injection of one sperm into each egg collected during the IVF process. If a person is experiencing other symptoms, they may wish to speak to a doctor. Therefore, data estimating the prevalence of infertility cited by various sources differs significantly.[8] A couple that tries unsuccessfully to have a child after a certain period of time (often a short period, but definitions vary) is sometimes said to be subfertile, meaning less fertile than a typical couple. Adding recombinant human FSH to HCG has been shown to be effective in achieving spermatogenesis in most patients.[18] Select patients with adult-onset idiopathic hypogonadotropic hypogonadism may respond to clomiphene citrate therapy.[19] Prader-Willi syndrome Patients have characteristic obesity, mental retardation, small hands and feet, and hypogonadotropic hypogonadism due to a GnRH deficiency.

Prolactinomas or the intakes of dopamine antagonists (typical antipsychotics for example) cause hyperprolactinemia. Old cervix disruptions or infections of the cervical canal are a possible cause.

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Smoking during pregnancy increases the chance of pregnancy loss. After interviewing the couple together, the man and woman should be interviewed separately to obtain confidential information. A doctor or WHNP takes a medical history and gives a physical examination. Your doctor will carry out a series of tests to diagnose what’s causing your fertility difficulties.  There are many reasons why you may have problems conceiving, including:  Your sperm does not have the concentration, motility or shape required to conceive Existing medical conditions that affect your fertility, such as issues with sperm production or duct obstructions  Your sperm may not be strong or healthy enough to fertilise your partner’s egg  As your partner gets older, her fertility quickly declines3 Depending on the cause, your doctor will recommend a treatment path for you. Compensatory and Obligatory Renal Growth in Rats. (PDF, 1 MB) American Journal of Physiology, 1974. Gonadotropin-releasing hormone (GnRH) from the hypothalamus stimulates the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary.

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In the 1980s, a pure form of FSH became available. Most couples (about 84%) who have regular sexual intercourse (that is, every two to three days) and who do not use contraception get pregnant within a year. One of the requirements for this procedure is that a woman should have at least 1 undamaged fallopian tube. Affected individuals displayed more severe forms of infertility such as azoospermia and severe oligozoospermia.[27] Other causes[edit] Factors that can cause male as well as female infertility are: DNA damage DNA damage reduces fertility in female ovocytes, as caused by smoking,[28] other xenobiotic DNA damaging agents (such as radiation or chemotherapy)[29] or accumulation of the oxidative DNA damage 8-hydroxy-deoxyguanosine[30] DNA damage reduces fertility in male sperm, as caused by oxidative DNA damage,[31] smoking,[28] other xenobiotic DNA damaging agents (such as drugs or chemotherapy)[32] or other DNA damaging agents including reactive oxygen species, fever or high testicular temperature.[33] The damaged DNA related to infertility manifests itself by the increased susceptibility to denaturation inducible by heat or acid [34] or by the presence of double-strand breaks that can be detected by the TUNEL assay.[35] General factors Diabetes mellitus,[36][37] thyroid disorders,[38] undiagnosed and untreated coeliac disease,[39][40][41][42] adrenal disease[43] Hypothalamic-pituitary factors Hyperprolactinemia Hypopituitarism The presence of anti-thyroid antibodies is associated with an increased risk of unexplained subfertility with an odds ratio of 1. Intrauterine insemination. For this procedure, after semen gets rinsed with a special solution, a doctor places it into your uterus when you're ovulating.

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In some cases, the cause of infertility or subfertility could not be suspected from the history taking and clinical examination. These tests are used to determine gland failure or obstruction. Microscopic Vasectomy Reversal. (PDF, 31 MB) Fertility and Sterility, 1977. The chance of a live birth following treatment is nearly 50% [25]. These medicines are listed below: sulfasalazine – an anti-inflammatory medicine used to treat conditions such as Crohn's disease and rheumatoid arthritis; sulfasalazine can decrease the number of sperm, but its effects are temporary and your sperm count should return to normal when you stop taking it anabolic steroids – are often used illegally to build muscle and improve athletic performance; long-term abuse of anabolic steroids can reduce sperm count and sperm mobility chemotherapy – medicines used in chemotherapy can sometimes severely reduce sperm production herbal remedies – some herbal remedies, such as root extracts of the Chinese herb Tripterygium wilfordii, can affect the production of sperm or reduce the size of your testicles Illegal drugs, such as marijuana and cocaine, can also affect semen quality. Men who are underweight tend to have lower sperm concentrations than those who are at a normal BMI. If oligospermia or azoospermia is noted, hypogonadism should be suspected. Medical conditions Some medical conditions can affect fertility. Intracytoplasmatic Sperm Injection (ICSI) An intracytoplasmatic sperm injection is also a form of artificial insemination. Outcome of Intracytoplasmic Sperm Injection with Testicular Spermatozoa in Obstructive and Non-obstructive Azoospermia. (PDF, 426 KB) Human Reproduction, 1996. Ovarian hyperstimulation syndrome (OHSS) usually results from taking medications to stimulate the ovaries, such as clomifene and gonadotrophins. Consequently, the patient with PCOS becomes responsive to CC ovulation induction.