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Histologic endometrial dating is not considered reliable nor is it predictive of fertility. Evaluation of cervical mucus is unreliable; therefore, investigation is not helpful with the management of infertility.

Antisperm antibody test Sperm contain unique antigens that are not recognized as self by the body's immune system because of the blood-testis barrier. Options include intrauterine insemination (also known as IUI) or IVF with intracytoplasmic sperm injection (also known as ICSI). The patients often suffer from appearances of virilization and manlike hair patterns. If conception does not occur after many months or years of trying, it can lead to stress and possibly depression.

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Chromosomal abnormalities An estimated 6-13% of infertile men have chromosomal abnormalities (compared with 0. This may be because the ovaries do not contain eggs. As the major causes of infertility are sperm abnormalities, ovulation dysfunction, and fallopian tube obstruction, the preliminary adviced investigations for the infertile couple should be focused on semen analysis (to be compared with the WHO reference values [27]), detection of ovarian function by hormonal assay (early follicular FSH and LH levels, and mid-luteal progesterone), and evaluation of tubal patency by hysterosalpingography (HSG) [17-32], (Appendix 3). Affected individuals displayed more severe forms of infertility such as azoospermia and severe oligozoospermia.[27] Other causes[edit] Factors that can cause male as well as female infertility are: DNA damage DNA damage reduces fertility in female ovocytes, as caused by smoking,[28] other xenobiotic DNA damaging agents (such as radiation or chemotherapy)[29] or accumulation of the oxidative DNA damage 8-hydroxy-deoxyguanosine[30] DNA damage reduces fertility in male sperm, as caused by oxidative DNA damage,[31] smoking,[28] other xenobiotic DNA damaging agents (such as drugs or chemotherapy)[32] or other DNA damaging agents including reactive oxygen species, fever or high testicular temperature.[33] The damaged DNA related to infertility manifests itself by the increased susceptibility to denaturation inducible by heat or acid [34] or by the presence of double-strand breaks that can be detected by the TUNEL assay.[35] General factors Diabetes mellitus,[36][37] thyroid disorders,[38] undiagnosed and untreated coeliac disease,[39][40][41][42] adrenal disease[43] Hypothalamic-pituitary factors Hyperprolactinemia Hypopituitarism The presence of anti-thyroid antibodies is associated with an increased risk of unexplained subfertility with an odds ratio of 1. Microscopic Vasovasostomy and Spermatogenesis. (PDF, 1 MB) The Journal of Urology, 1977. Basal body temperatures are no longer considered a reliable indicator of ovulation, and are not recommended for evaluating ovulation.

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Pregnancy Caused by Sperm from Vasa Efferentia. (PDF, 1 MB) Fertility and Sterility, 1988. Blocked tubes Sperm travel in tubes from the man’s testes to the penis. Abnormalities of the uterus like the uterus bicornis, uterus septa or hypoplasia of the uterus less frequently result in contraceptional barriers but can cause miscarriages. The follicle should develop to a diameter of 23-24 mm before a spontaneous LH surge occurs.

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In this condition, semen ejaculates backwards into the bladder instead of out the penis. The entire process of development from spermatogonium to spermatid takes 74 days and is described in 14 steps; as they mature, the developing spermatids progress closer to the lumen of the seminiferous tubule. Experts differ in their approach, but here are some of the tests you can expect: Continued Sperm and semen analysis. Infection: Some infections, such as gonorrhea or inflammation of the testicles, can affect sperm production or sperm health or can cause scarring that blocks the passage of sperm. An evaluation by a physician is the only way to sort it out. Treatment of hydrosalpinx (distal tubal obstruction) with salpingostomy can be performed through microsurgery or operative laparoscopy. Some women are infertile because their ovaries do not mature and release eggs. However, early referral of infertile couples to a dedicated specialist infertility clinic may be indicated to increase their chance of pregnancy (Table ). The likelihood of fertilization improves significantly for men with low sperm concentrations. Simultaneous Treatment of the Wife in Infertile Couples with Oligospermia. (PDF, 4 MB) Fertility and Sterility, 1983. Disorders of the hypothalamus lead to hypogonadotropic hypogonadism.