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These include: non-steroidal anti-inflammatory drugs (NSAIDs) – long-term use or a high dosage of NSAIDs, such as ibuprofen or aspirin, can make it more difficult to conceive chemotherapy – medicines used for chemotherapy can sometimes cause ovarian failure, which means your ovaries will no longer be able to function properly neuroleptic medicines – antipsychotic medicines often used to treat psychosis; they can sometimes cause missed periods or infertility spironolactone – a type of medicine used to treat fluid retention (oedema); fertility should recover around 2 months after you stop taking spironolactone Illegal drugs, such as marijuana and cocaine, can seriously affect fertility and make ovulation more difficult. Malformation of the eggs themselves may complicate conception.

Steroids used to build muscles can shrink the testes and may lead to decreased sperm production. The identification of anovulation is not easy; contrary to what is commonly believed, women undergoing anovulation still have (more or less) regular periods. In addition to a careful history, a physical evaluation may also be performed.

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This is called luteinised unruptured follicle syndrome (LUFS). When Predictions Don’t Predict. (PDF, 549 KB) The Australian and New Zealand Journal of Obstetrics and Gynaecology, 1991.

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The laboratory evaluation begins with a semen analysis. Couples may decide to go ahead regardless if the desire to become pregnant is very strong. Women with anovulation may be treated in the primary care setting with clomiphene to induce ovulation.

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Removal of polyps by the minimally invasive procedure hysteroscopy is associated with a doubling of pregnancy rate. For example, polycystic ovarian syndrome is when the eggs only partially developed within the ovary and there is an excess of male hormones. Although many of these can be treated through surgery or hormonal substitutions, some may be indefinite.[59] Infertility associated with viable, but immotile sperm may be caused by primary ciliary dyskinesia. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics.